kallikrein-10; normal epithelial cell-specific 1; protease serine-like 1 (KLK10, NES1, PRSSL1)

Function

• tumor-suppressor role for NES1 in breast cancer & prostate cancer

Structure

• belongs to the peptidase S1 family, kallikrein subfamily
• contains 1 peptidase S1 domain

Compartment

secreted (probable)

Expression

• expressed in breast, ovary & prostate

Pathology

• down-regulated during breast cancer progression

More general terms

• kallikrein
• glycoprotein
• anti-oncoprotein (tumor suppressor protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5655
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5655
• OMIM: https://mirror.omim.org/entry/602673
• UniProt: http://www.uniprot.org/uniprot/O43240.html