Zn+2 finger RNA-binding protein (hZFR, M-phase phosphoprotein homolog, ZFR)

Function

• role in postimplantation & gastrulation stages of development
• involved in the nucleocytoplasmic shuttling of STAU2
• binds to DNA & RNA (putative)
• found in a cytoplasmic RNP complex with STAU2
• interacts with STAU2
• does not interact with STAU1 (putative)

Structure

contains 1 DZF domain

Compartment

• nucleus (putative), cytoplasm, cytoplasmic granule
• associated with chromosome foci in meiotic cells
• localizes in somatodendritic compartment of primary hippocampal neurons
• colocalizes with STAU2 in several cytosolic RNA granules

Expression

• expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain & kidney

More general terms

• nuclear protein
• phosphoprotein
• RNA-binding protein
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96KR1.html