RNA-binding protein 40 (RNA-binding motif protein 40, RNA-binding region-containing protein 3, U11/U12 small nuclear ribonucleoprotein 65 kD protein, U11/U12 snRNP 65 kD protein, U11/U12-65K, RNPC3, KIAA1839, RBM40, RNP)

Function

• RNA-binding protein
• role in pre-mRNA splicing
• participates in pre-mRNA U12-dependent splicing
• binds to the 3'-stem-loop of m(7)G-capped U12 snRNA
• component of the U11/U12 snRNPs that are part of the U12-type spliceosome
• found in a complex with m(7)G-capped U12 snRNA
• interacts with PDCD7

Structure

contains 2 RRM (RNA recognition motif) domains

Compartment

nucleus

Expression

• highly expressed in pancreas & kidney
• detected at lower levels in heart, brain, placenta, lung, liver, spleen, thymus, prostate, testis, ovary, small intestine, colon & leukocytes

More general terms

• nuclear protein
• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96LT9.html