SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP, C14orf156, DC23, DC50, PD04872)

Function

• RNA-binding protein
• nuclear receptor corepressor
• binds SRA RNA, & represses SRA-mediated nuclear receptor coactivation
• binds STR7 loop of SRA RNA
• able to repress glucocorticoid receptor, androgen receptor, thyroid receptor & VDR-mediated transactivation

Structure

contains 1 RRM domain (RNA recognition motif)

Compartment

• mitochondrion, nucleus
• predominantly mitochondrial, some fraction is nuclear
• in the nucleus, recruited to nuclear receptor target promoters

Expression

• ubiquitously expressed, with highest level in heart, liver, skeletal muscle & testis

More general terms

• mitochondrial protein
• nuclear protein
• phosphoprotein
• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9GZT3.html