nucleolar protein 8 (nucleolar protein Nop132, NOL8, C9orf34, NOP132)

Function

• role in regulation of gene expression at post-transcriptional level or in ribosome biogenesis
• phosphorylated
• interacts with the GTP form of RRAGA, RRAGC & RRAGD
• interacts with NIP7

Structure

contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus, nucleolus

Alternative splicing

named isoforms=4

Expression

• detected in skeletal muscle

Pathology

• role in survival of diffuse-type gastric cancer cells
• up-regulated in diffuse-type gastric cancers
• role in regulation of gene expression at post-transcriptional level or in ribosome biogenesis in cancer cells

More general terms

• nuclear protein
• RNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q76FK4.html