RNA-binding protein MEX3B (RING finger & KH domain-containing protein 3, RING finger protein 195, RKHD3, KIAA2009, MEX3B, RNF195)

Function

• RNA-binding protein, binds RNA through its KH domains
• role in post- transcriptional regulation (putative)
• phosphorylated

Structure

• contains 2 KH domains
• contains 1 RING-type zinc finger

Compartment

• nucleus, cytoplasm, P-body
• predominantly expressed in the cytoplasm
• shuttles between cytoplasm & nucleus through the CRM1 export pathway

Alternative splicing

named isoforms=2

Expression

• highest levels found in fetal brain & testis
• detected in the adult intestinal epithelium, specifically in goblet cell at protein level

More general terms

• ring finger protein
• RNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6ZN04.html