CUG-BP- & ETR-3-like factor 3 (Bruno-like protein 1, RNA-binding protein BRUNOL-1, ELAV-type RNA-binding protein 1, ETR-1, trinucleotide repeat-containing gene 4 protein, expanded repeat-domain protein CAG/CTG 4, CAG repeat-domain protein, TNRC4, BRUNOL1, CAGH4, CELF3, ERDA4)
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Function
- RNA-binding protein
- role in the regulation of pre-mRNA alternative splicing
- mediates exon inclusion &/or exclusion in pre-mRNA that are subject to tissue-specific & developmentally regulated alternative splicing
- specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition
- binds to muscle-specific splicing enhancer (MSE) intronic sites flanking alternative exon 5 of TNNT2 pre-mRNA
Structure
- belongs to the CELF/BRUNOL family
- contains 3 RRM domains (RNA recognition motif)
Compartment
Alternative splicing
named isoforms=3
Expression
expressed in brain
Polymorphism
- poly-Gln tract in AAK07474 may be polymorphic