insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3, IGF-2 mRNA-binding protein 3, IMP-3, KH domain-containing protein overexpressed in cancer, hKOC, VICKZ family member 3, IGF2BP3, IMP3, KOC1, VICKZ3)
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Function
- RNA-binding protein
- regulator of mRNA translation & stability
- binds to the 5'-UTR of IGF2 mRNA
- binds to sequences in the 3'-UTR of CD44 mRNA
Structure
- homodimer & multimer
- belongs to the RRM IMP/VICKZ family
- contains 4 KH domains
- contains 2 RRM repeats (RNA recognition motif)
Compartment
- nucleus, cytoplasm
- found in lamellipodia of leading edge, in perinuclear region, & beneath the plasma membrane
- subcytoplasmic localization is cell specific & regulated by cell contact & growth
- localized at connecting piece & tail of spermatozoa
- colocalized with CD44 mRNA in RNP granules
Alternative splicing
named isoforms=3
Expression
- expressed in fetal liver, lung, kidney, thymus, placenta, follicles of ovary & gonocytes of testis
- expressed in growing oocytes, spermatogonia & semen
- ubiquitously during fetal development at 8 & 14 weeks of gestation
Pathology
- expressed in cervical cancer (adenocarcinoma)
- expressed in testicular cancer
- expressed in pancreatic cancer
- expressed in renal-cell carcinomas
- expressed in ovarian cancer
- autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas