2'-5'-oligoadenylate synthetase 3 ([2-5']oligo[A] synthetase 3, 2-5A synthetase 3, p100 OAS, p100OAS, OAS3)

Function

• role in mediating resistance to viral infection, cell growth, differentiation, apoptosis
• synthesizes preferentially dimeric 2',5'-oligoadenylate molecules; GTP can be an alternative substrate
• binds double-stranded RNA & polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate latent RNase L (cleaves single-stranded RNAs)
• induced by interferons

Expression

expressed placenta trophoblast

More general terms

• nucleotidyltransferase
• RNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/603351
• UniProt: http://www.uniprot.org/uniprot/Q9Y6K5.html