protein NGX6; nasopharyngeal carcinoma-associated gene 6 protein; protein NAG-5 (C9orf127, NGX6, TMEM8B)

Function

• may function as a regulator of the EGFR pathway
• probable tumor suppressor
• may function in cell growth, proliferation & adhesion
• isoform 2 (via its cytoplasmic part) interacts with EZR

Structure

• isoform 2 is N-glycosylated
• belongs to the NGX6 family
• contains 1 EGF-like domain

Compartment

• isoform 2: cell membrane
• cytoplasm, nucleus (probable)
• also detected in mitochondrion & endoplasmic reticulum

Alternative splicing

named isoforms=3

Pathology

• isoform 2 is down-regulated in nasopharyngeal carcinoma cells

More general terms

• glycoprotein
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5175
• UniProt: http://www.uniprot.org/uniprot/A6NDV4.html