immunoglobulin superfamily member 5 (junctional adhesion molecule 4, IGSF5, JAM4)

Function

• provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus & small intestinal epithelial cells
• mediates Ca+2-independent homophilic cell adhesion
• in testis, may function as a cell adhesion molecule rather than a tight-junction protein
• may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, & Sertoli cells- Sertoli cells (putative)
• interacts with MAGI1 at tight junctions, forms a tripartite complex with NPHS1 (putative)

interacts with LNX1 isoform 2 via its PDZ 2 domain, may also interact with other isoforms containing this domain (putative)

Structure

• belongs to the immunoglobulin superfamily
• contains 2 Ig-like V-type domain (immunoglobulin-like)

Compartment

• cell membrane (putative)
• tight junction

More general terms

• glycoprotein
• membrane protein
• immunoglobulin superfamily protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NSI5.html