junctional sarcoplasmic reticulum protein 1 (junctional-face membrane protein of 45 kD homolog, JP-45, JSRP1, JP45)

Function

• may function as a regulator of the voltage-sensitive Ca+2 channel CACNA1S
• may regulate CACNA1S membrane targeting & activity
• may function in excitation/contraction coupling in muscle cells (putative)
• interacts with CACNA1S, CACNB1 & calsequestrin

Compartment

• sarcoplasmic reticulum membrane
• endoplasmic reticulum membrane
• colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes (putative)

Notes

uncertain whether Met-1 or Met-3 is the initiator

More general terms

• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1263
• OMIM: https://mirror.omim.org/entry/608743
• UniProt: http://www.uniprot.org/uniprot/Q96MG2.html