heparan-sulfate 6-O-sulfotransferase 2 (HS6ST-2, HS6ST2)

Function

• 6-O-sulfation enzyme
• catalyzes transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

3'-phosphoadenylyl sulfate + [heparansulfate]-glucosamine <--> adenosine 3',5'-bisphosphate + [heparansulfate]-glucosamine 6-sulfate

Structure

belongs to the sulfotransferase 6 family

Compartment

membrane

Alternative splicing

named isoforms=3

More general terms

• glycoprotein
• membrane protein
• sulfotransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q96MM7.html