fatty acyl-CoA reductase 2 (male sterility domain- containing protein 1, MLSTD1, FAR2)

Function

• catalyzes reduction of fatty acyl-CoA to fatty alcohols
• preferred substrates are C16, C18, C18:1 & C18:2 but low activity can be observed with C10-C14 substrates

Fatty acyl-CoA + 2 NADPH = fatty alcohol + 2 NADP+

Structure

belongs to the fatty acyl-CoA reductase family

Compartment

• peroxisome membrane
• endoplasmic reticulum membrane
• peroxisome in cells expressing low levels of the protein
• peroxisome & endoplasmic reticulum in cells expressing high levels of the protein

More general terms

• oxidoreductase
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96K12.html