UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5; BGnT-5; Beta1,3-N-acetylglucosaminyltransferase-5; lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; B3GNT5

Function

• glycosylation pathway
• beta-1,3-N-acetylglucosaminyltransferase
• role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, including HNK-1 & Lewis X carbohydrate structures
• strong activity toward lactosylceramide (LacCer) & neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in synthesis of Lc(3)Cer & nLc(5)Cer (neolactopentaosylceramide), respectively
• role in regulating neolacto-series glycolipid synthesis during embryonic development

Structure

belongs to the glycosyltransferase 31 family

Compartment

Golgi membrane

Expression

• widely expressed
• highly expressed in lung, colon, placenta, testis, pituitary gland & cerebellum
• weakly expressed in brain, liver, spleen, lymph node & thymus
• up-regulated by stimulation with retinoic acid
• down-regulated with 12-O-tetradecanoylphorbol-13-acetate

More general terms

• beta-1,3-N-acetylglucoaminyltransferase (B3GNT1)
• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BYG0.html