UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (Beta3Gn-T6, BGnT-6, Beta1,3-N-acetylglucosaminyltransferase-6, core 3 synthase, B3GNT6)

Function

• glycosylation pathway
• beta-1,3-N-acetylglucosaminyltransferase
• synthesizes core 3 structure of the O-glycan, an important precursor in biosynthesis of mucin-type glycoproteins
• role in the synthesis of mucin-type O-glycans in digestive organs

Structure

belongs to the glycosyltransferase 31 family

Compartment

Golgi membrane

Alternative splicing

named isoforms=2

Expression

• present in stomach & colon (at protein level)
• restricted in the stomach, colon & small intestine, where core 3 structure is present

Pathology

• down-regulated in gastric & colorectal carcinomas
• injection into nude mice significantly suppresses lung metastasis

More general terms

• beta-1,3-N-acetylglucoaminyltransferase (B3GNT1)
• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6ZMB0.html