heparan sulfate 2-O-sulfotransferase 1; 2-O-sulfotransferase (2OST, HS2ST1, HS2ST, KIAA0448)

Function

• catalyzes transfer of sulfate to the C2-position of hexuronic acid residues within the maturing heparan sulfate
• mediates 2-O-sulfation of both L-iduronyl & D-glucuronyl residues
• interacts with C5-epimerase GLCE

Structure

• N-glycosylated

Compartment

Golgi membrane

Alternative splicing

named isoforms=3

More general terms

• sulfotransferase
• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/604844
• UniProt: http://www.uniprot.org/uniprot/Q7LGA3.html