D-glucuronyl C5-epimerase; heparin/heparan sulfate:glucuronic acid C5-epimerase (GLCE, KIAA0836)

Function

• converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acids
• heparin & heparan sulfate biosynthesis
• interacts with HS2ST1

Structure

belongs to the D-glucuronyl C5-epimerase family

Compartment

• Golgi
• single-pass type 2 membrane protein (putative)

More general terms

• epimerase
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26035
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26035
• UniProt: http://www.uniprot.org/uniprot/O94923.html