Na+/hydrogen exchanger 10; Na+/H+ exchanger 10; sperm-specific Na+/H+ exchanger; sNHE; solute carrier family 9 member 10 (SLC9A10, SLC9C1)

Function

• sperm-specific Na+/hydrogen exchanger
• involved in intracellular pH regulation of spermatozoa
• required for sperm motility & fertility
• involved in sperm cell hyperactivation, a step needed for sperm motility
• required for the expression & bicarbonate regulation of the soluble adenylyl cyclase (putative)
• interacts with soluble adenylyl cyclase

Structure

• ion transport-like region is related to the membrane segments of voltage-gated ion channels
• belongs to the Na+/H+ exchanger (TC 2.A.36.5.1) family
• contains 1 cyclic nucleotide-binding domain

Compartment

• cell projection, cilium, flagellum, membrane

Alternative splicing

named isoforms=2

More general terms

• glycoprotein
• membrane protein
• solute carrier family 9 (SLC9, SLC9A)

Database

• UniProt: http://www.uniprot.org/uniprot/Q4G0N8.html