trem-like transcript 1 protein (TLT-1, triggering receptor expressed on myeloid cells-like protein 1, TREML1, TLT1, UNQ1825/PRO3438)

Function

• cell surface receptor that may play a role in the innate & adaptive immune response
• when phosphorylated, interacts with PTPN6
• when phosphorylated, interacts with PTPN11
• phosphorylated on Tyr

Structure

• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• cell membrane, cytoplasm
• sequestered in cytoplasmic vesicles in resting platelets
• transported to the cell surface after stimulation by thrombin
• soluble fragments can be released into plasma by proteolysis

Alternative splicing

named isoforms=3

Expression

• detected in platelets

Pathology

• detected in monocytic leukemia & in T-cell leukemia

More general terms

• phosphoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86YW5.html