apolipoprotein O (protein FAM121B) (APOO FAM121B My025 UNQ1866/PRO4302)

Function

• promotes cholesterol efflux from macrophage cells
• detected in HDL, LDL & VLDL
• secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL
• may be involved in myocardium-protective mechanisms against lipid accumulation

Structure

• belongs to the apolipoprotein O family
• O-glycosylated, glycosaminoglycan of chondroitin-sulfate

Compartment

membrane, secreted

Alternative splicing

named isoforms=2

Expression

• expressed in all tissues examined
• up-regulated in diabetic heart

More general terms

• apolipoprotein
• glycoprotein
• membrane protein
• secreted protein

Additional terms

• apolipoprotein O-like (protein FAM121A, APOOL, CXorf33, FAM121A, UNQ8193/PRO23204)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BUR5.html