Sad1/unc-84-like protein 2 (Rab5-interacting protein, Rab5IP, UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2)

Function

• interacts with RAB5A

Structure

• contains 1 Unc84 (SUN) domain
• Unc84 domain may play a role in the nuclear anchoring &/or migration

Compartment

• nucleus membrane
• endosome membrane

Expression

• widely expressed
• highly expressed in heart, lung & muscle
• weakly expressed in fetal heart

Pathology

• slightly overexpressed in some heart tissues from patients with congenital heart defects

Notes

uncertain whether Met-1 or Met-50 is the initiator

More general terms

• membrane protein
• nuclear protein
• phosphoprotein

Additional terms

• protein C20orf24 (Rab5-interacting protein, RIP5, C20orf24)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UH99.html