cysteine-rich motor neuron 1 protein (CRIM-1, cysteine-rich repeat-containing protein S52, CRIM1)

Function

• role in CNS development by interacting with growth factors implicated in motor neuron differentiation & survival (putative)
• role in capillary formation & maintenance during angiogenesis (putative)
• modulates BMP activity by affecting its processing & delivery to the cell surface
• interacts with BMP4 & BMP7

Structure

• N-glycosylated
• contains 4 antistasin-like domains
• contains 1 IGFBP domain
• contains 6 VWFC domains

Compartment

cell membrane, secreted

Expression

• expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver & small intestine
• expressed in blood vessels (at protein level)

More general terms

• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/606189
• UniProt: http://www.uniprot.org/uniprot/Q9NZV1.html