roundabout homolog 3 (roundabout-like protein 3, ROBO3)

Function

• role in neural development
  • role in axonal navigation at ventral midline of the neural tub
• role in spinal cord development
  • role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (putative)
• required for hindbrain axon midline crossing
• probably interacts with SLIT2

Structure

• belongs to the immunoglobulin superfamily, ROBO family
• contains 3 fibronectin F3 modules
  • contains 5 Ig-like C2-type domains (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=2

Pathology

• defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis

More general terms

• immunoglobulin superfamily protein
• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/607313
• OMIM: https://mirror.omim.org/entry/608630
• UniProt: http://www.uniprot.org/uniprot/Q96MS0.html