leucine-rich repeat-containing protein 25 (monocyte & plasmacytoid-activated protein, LRRC25, MAPA, UNQ6169/PRO20174)

Function

• role in activation of cells of innate & acquired immunity

Structure

• contains 2 LRR repeats (leucine-rich repeats)

Compartment

membrane

Expression

• expressed in plasmacytoid dendritic cells, monocyte-derived dendritic cells, granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow > lymph nodes, fetal liver, appendix
• down-regulated in CD40-activated monocyte-derived dendritic cells

More general terms

• membrane protein
• glycoprotein
• leucine-rich repeat-containing protein (LRRC)

Database

• OMIM: https://mirror.omim.org/entry/607518
• UniProt: http://www.uniprot.org/uniprot/Q8N386.html