lactadherin (milk fat globule-EGF factor 8, MFG-E8, HMFG, breast epithelial antigen BA46, MFGM, [Contains: Lactadherin short form; Medin], MFGE8)

Function

• specific ligand for the alpha-v/beta-3 & alpha-v/beta-5 receptors
• also binds to phosphatidylserine-enriched cell surfaces (receptor-independen)
• binds zona pellucida, role in gamete interaction

Structure

• medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273
• contains 1 EGF-like domain
• contains 2 F5/8 type C domains

Compartment

membrane, peripheral membrane

Expression

• expressed on mammary epithelial cell surfaces & in aortic media

Pathology

• binds specifically to rotavirus & inhibits its replication
• medin is the main constituent of aortic medial amyloid
• overexpressed in several carcinomas

More general terms

• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/602281
• UniProt: http://www.uniprot.org/uniprot/Q08431.html