attractin (Mahogany homolog, DPPT-L, ATRN, KIAA0548, MGCA)
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Function
- initial immune cell clustering during inflammatory response
- regulates chemotactic activity of chemokines (putative)
- activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of membrane isoform followed by the release of secreted isoform
- melanocortin signaling pathways that regulate energy homeostasis & hair color (putative)
- low-affinity receptor for agouti (putative)
- myelination in the central nervous system
Structure
- contains 1 C-type lectin domain.
- contains 1 CUB domain.
- contains 1 EGF-like domain.
- contains 6 Kelch repeats.
- contains 2 laminin EGF-like domains
Compartment
- isoform 1: cell membrane
- isoforms 2,3,4,5: secreted
Alternative splicing
named isoforms=3
Expression
- expressed & secreted by activated T lymphocytes
- expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow, fetal liver
- very low levels found in thymus
- isoform 2 (secreted) is the major isoform in peripheral blood leukocytes