plasmalemma vesicle-associated protein (plasmalemma vesicle protein 1, PV-1, fenestrated endothelial-linked structure protein, PLVAP, FELS, PV1)
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Function
- formation of stomatal & fenestral diaphragms of caveolae
- microvascular permeability
Structure
homodimer
Compartment
- cell membrane, caveola, cytoplasm, perinuclear region
- found in fenestral & stomatal diaphragms in fenestrated endothelia & transendothelial channels
- colocalizes with CAV1 in perinuclear region
Expression
- expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver
Pathology
- expressed in tumor-associated endothelium