Unc-13 homolog B (Munc13-2, munc13, UNC13B, UNC13, C. elegans homolog of B)

Function

• vesicle maturation during exocytosis
• target of the diacylglycerol second messenger pathway
• neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion
• participates in the activity-dependent refilling of readily releasable vesicle pool (RRP).
• synaptic vesicle maturation in a subset of excitatory/ glutamatergic but not inhibitory/GABA-mediated synapses
• interacts with RIMS1

Compartment

• cytoplasm
• peripheral membrane
• localized to synapses
• translocated to the plasma membrane in response to phorbol ester binding

Expression

• expressed in kidney cortical epithelial cells & brain

More general terms

• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/605836
• UniProt: http://www.uniprot.org/uniprot/O14795.html