rhomboid-related protein 1; RRP; rhomboid-like protein 1 (RHBDL1, RHBDL)

Function

• may be involved in regulated intramembrane proteolysis & subsequent release of functional polypeptides from their membrane anchors (putative)
• cleaves type-1 transmembrane domains using a catalytic dyad composed of serine & histidine that are contributed by different transmembrane domains

Structure

• belongs to the peptidase S54 family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• detected in heart, brain, skeletal muscle & kidney

More general terms

• rhomboid-related protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9028
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9028
• OMIM: https://mirror.omim.org/entry/603264
• UniProt: http://www.uniprot.org/uniprot/O75783.html