Kv channel-interacting protein 1; KChIP1; A-type K+ channel modulatory protein 1; K+ channel-interacting protein 1; vesicle APC-binding protein (KCNIP1, KCHIP1)

Function

• regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type K+ channels
• modulates channels density, inactivation kinetics & rate of recovery from inactivation
• Ca+2-dependent
• in vitro, modulates Kv4.1 & Kv4.2 currents
• Kv4.2 trafficking to the cell surface
• component of heteromultimeric K+ channels
• interacts with KCND3 & the N- terminal domain of KCND2
• probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 & KCND2
• interacts with Naja atra venom CTX3

Structure

• self-associates to form homodimers & homotetramers
• belongs to the recoverin family
• contains 4 EF-hand domains

Compartment

cell membrane

Alternative splicing

named isoforms=5

Expression

• isoform 1 & isoform 2 expressed in brain, kidney
• isoform 1 also expressed in liver, pancreas, skeletal muscle, small intestine, testis
• isoform 2 also expressed in lung, pancreas, leukocytes, prostate, thymus

More general terms

• membrane protein
• Ca+2 binding protein

Component of

• Kv4.2/KCNIP2 channel complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30820
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:30820
• OMIM: https://mirror.omim.org/entry/604660
• UniProt: http://www.uniprot.org/uniprot/Q9NZI2.html