recoverin; cancer-associated retinopathy protein; protein CAR; visinin; frequinin; S-modulin (RCVRN, RCV1)
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Function
- seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin
- may be involved in the inhibition of the phosphorylation of rhodopsin (Ca+2-dependent); Ca+2-bound recoverin prolongs the photoresponse
- binds two Ca+2; one with high affinity, the other with low affinity
Structure
- belongs to the recoverin family
- contains 4 EF-hand domains
Expression
Pathology
- identified as the antigen in cancer-associated retinopathy (anti-Car antibody)
Laboratory
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P35243.html
- ↑ Heizmann CW, Braun K. Changes in Ca(2+)-binding proteins in human neurodegenerative disorders. Trends Neurosci. 1992 Jul;15(7):259-64. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1381122
- ↑ Hurley JB, Dizhoor AM, Ray S, Stryer L. Recoverin's role: conclusion withdrawn. Science. 1993 May 7;260(5109):740. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8097896