ERGIC-53 protein; ER-Golgi intermediate compartment 53 kD protein; Gp58; intracellular mannose-specific lectin MR60; lectin mannose-binding 1 (LMAN1, ERGIC53, F5F8D)

Function

• mannose-specific lectin
• may recognize sugars of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors & play a role in the sorting or recycling of proteins, lipids, or both
• interacts with MCFD2. (see LMAN1-MCFD2 complex)

Structure

• forms disulfide-linked dimers & hexamers.

Compartment

• endoplasmic reticulum-Golgi intermediate compartment (ERGIC)

Expression

ubiquitous expression

Pathology

• defects in ERGIC53 are a cause of multiple-coagulation-factor deficiency 1 (MCFD1)

More general terms

• Ca+2 binding protein
• glycoprotein
• membrane protein
• oligomerizing protein

Component of

• LMAN1 (ERGIC53) - MCFD2 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3998
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3998
• OMIM: https://mirror.omim.org/entry/227300
• OMIM: https://mirror.omim.org/entry/601567
• UniProt: http://www.uniprot.org/uniprot/P49257.html