regulator of G-protein signaling 16; A28-RGS14P; retinal-specific RGS; RGS-r; hRGS-r; retinally abundant regulator of G-protein signaling (RGS16, RGSR)

Function

• inhibits signal transduction by increasing GTPase activity of G-alpha subunits increasing the amount of inactive GDP-bound form
• binds to Gi-alpha & Go-alpha,
• does not bind Gs-alpha
• may play a role in regulating kinetics of signaling in the phototransduction cascade
• palmitoylated on Cys-2 &/or Cys-12 (putative)
• phosphorylation on Tyr-168 upon EGFR stimulation
• enhanced GTPase accelerating (GAP) activity on Gi-alpha

Structure

contains 1 RGS domain

Expression

• abundantly expressed in retina
• lower levels of expression in most other tissues

More general terms

• regulator of G-protein signaling
• phosphoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6004
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6004
• OMIM: https://mirror.omim.org/entry/602514
• UniProt: http://www.uniprot.org/uniprot/O15492.html