SLAM family member 6; activating NK receptor; NK-T-B-antigen; NTB-A (SLAMF6, KALI, UNQ6123/PRO20080)

Function

• triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors
• homodimer
• interacts with PTN6
• after phosphorylation interacts with PTN11, SH2D1A/SA

Structure

• contains 1 Ig-like (immunoglobulin-like) domain

Compartment

• cell membrane; single-pass type 1 membrane protein (probable)

Alternative splicing

named isoforms=2

Expression

• expressed by all (resting & activated) NK cells, T-cell & B-cells

More general terms

• SLAM family member protein
• phosphoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114836
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114836
• OMIM: https://mirror.omim.org/entry/606446
• UniProt: http://www.uniprot.org/uniprot/Q96DU3.html