serine/threonine-protein kinase LMTK1; apoptosis-associated tyrosine kinase; AATYK; brain apoptosis-associated tyrosine kinase; CDK5-binding protein; Lemur tyrosine kinase 1; p35-binding protein; p35BP (AATK, AATYK, KIAA0641, LMR,1 LMTK1)

Function

• neuronal differentiation
• interacts with CDK5, phosphorylated by CDK5
• autophosphorylates itself

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family
• contains 1 protein kinase domain

Compartment

• membrane, cytoplasm; perinuclear region
• predominantly perinuclear

Alternative splicing

named isoforms=3

Expression

• expressed in brain
• up-regulated during apoptosis

More general terms

• serine/threonine kinase
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9625
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9625
• OMIM: https://mirror.omim.org/entry/605276
• UniProt: http://www.uniprot.org/uniprot/Q6ZMQ8.html