galactose-3-O-sulfotransferase 3; gal3ST-3; beta-galactose-3-O-sulfotransferase 3; gal3ST3; gal-beta-1, 3-galNAc 3'-sulfotransferase 3 (GAL3ST3)

Function

• transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans & core2-branched O-glycans
• high activity towards gal-beta-1,4-GlcNAc, gal-beta-1,4(fuc-alpha-1,3)GlcNAc
• lower activity towards gal-beta-1,3(fuc-alpha-1,4)GlcNAc
• protein modification; carbohydrate sulfation

Cofactor: Mg+2

Kinetic parameters:

• pH dependence: optimum pH is 7.0-8.0

Structure

belongs to the galactose-3-O-sulfotransferase family

Compartment

• Golgi, Golgi stack membrane
• single-pass type 2 membrane protein (probable)

Expression

• highly expressed in thyroid, brain, kidney, heart & spinal cord

More general terms

• sulfotransferase
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89792
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:89792
• OMIM: https://mirror.omim.org/entry/608234
• UniProt: http://www.uniprot.org/uniprot/Q96A11.html