galactose-3-O-sulfotransferase 2; gal3ST-2; beta-galactose-3-O-sulfotransferase 2; gal-beta-1, 3-galNAc 3'-sulfotransferase 2; glycoprotein beta-gal 3'-sulfotransferase 2 (GAL3ST2, GP3ST)

Function

• transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues
• acts both on type 1 (gal-beta-1,3-GlcNAc) & type 2 (gal-beta-1,4-GlcNAc) chains with similar efficiency
• protein modification; carbohydrate sulfation

Kintetic parameters:

• pH dependence: optimum pH is 6.0-6.5

Inhibition:

• strongly inhibited by Cu+2 & Zn+2

Structure

belongs to the galactose-3-O-sulfotransferase family

Compartment

• Golgi, Golgi stack membrane
• single-pass type 2 membrane protein (probable)

Expression

• ubiquitous
• detected in heart, stomach, colon, liver & spleen, placenta, renal tubules, & neurons of the cerebral cortex

More general terms

• sulfotransferase
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64090
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64090
• OMIM: https://mirror.omim.org/entry/608237
• UniProt: http://www.uniprot.org/uniprot/Q9H3Q3.html