prostacyclin synthase; prostaglandin I2 synthase (PTGIS, CYP8, CYP8A1)

Function

• catalyzes isomerization of prostaglandin H2 to prostacyclin (prostaglandin I2)

Cofactor: heme group (putative)

Structure

belongs to the cytochrome P450 family

Compartment

• endoplasmic reticulum membrane

Expression

• widely expressed
• particularly abundant in ovary, heart, skeletal muscle, lung & prostate

More general terms

• isomerase
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5740
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5740
• OMIM: https://mirror.omim.org/entry/601699
• UniProt: http://www.uniprot.org/uniprot/Q16647.html