flavoprotein monooxygenase 3; dimethylaniline oxidase 3; dimethylaniline monooxygenase (N-oxide forming) 3 (FMO3)

Function

• role in the oxidative metabolism of xenobiotics including drugs & pesticides
• N-oxygenates primary aliphatic alkylamines as well as secondary & tertiary amines
• role in the metabolism of trimethylamine, via trimethylamine N-oxide
• also able to perform S-oxidation when acting on sulfide compounds

N,N-dimethylaniline + NADPH + O2
     <-->
N,N-dimethylaniline N-oxide + NADP+ + H2O

Cofactor: FAD

Structure

belongs to the FMO family

Compartment

• microsome membrane
• endoplasmic reticulum membrane

Expression

liver

Pathology

• defects in FMO3 are the cause of trimethylaminuria

More general terms

• flavoprotein mixed function oxidase
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P31513.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2328
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2328
• OMIM: https://mirror.omim.org/entry/136132
• OMIM: https://mirror.omim.org/entry/602079