acyloxyacyl hydrolase (AOAH)

Function

• removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides

3-(acyloxy)acyl group of bacterial toxin
                <-->
3-hydroxyacyl group of bacterial toxin + a fatty acid

Structure

• heterodimer
• both subunits contain a number of Cys that may form disulfide bridges
• contains 1 saposin B-type domain

More general terms

• glycoprotein
• membrane protein
• lipase
• hydrolase

Database

• UniProt: http://www.uniprot.org/uniprot/P28039.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:313
• OMIM: https://mirror.omim.org/entry/102593