protein MAL2 (MAL2)

Function

• member of the machinery of polarized transport
• required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway
• interacts with TPD52L2

Structure

• belongs to the MAL family
• contains 1 MARVEL domain

Compartment

• cell membrane; multi-pass membrane protein
• apical cell membrane; multi-pass membrane protein.
• endomembrane system
• cytoplasm, perinuclear region
• associated with lipid rafts
• in polarized epithelial cells, restricted to the apical surface
• in hepatocytes, as well as in polarized hepatoma hepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton
• in non-polarized hepG2 cells, distributed to the perinuclear region

Expression

• predominantly expressed in kidney, lung, & liver
• also found in thyroid gland, stomach &, at lower levels in testis & small intestine

More general terms

• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114569
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114569
• OMIM: https://mirror.omim.org/entry/609684
• UniProt: http://www.uniprot.org/uniprot/Q969L2.html