kinectin; kinesin receptor; CG-1 antigen (KTN1, CG1, KIAA0004)

Function

• receptor for kinesin
• kinesin-driven vesicle motility
• accumulates in integrin-based adhesion complexes upon integrin aggregation by fibronectin
• parallel homodimers formed between the membrane-bound & cytosolic form, & also between 2 cytosolic forms

Compartment

• endoplasmic reticulum
• vesicle membrane protein anchored to endoplasmic reticulum

Alternative splicing

named isoforms=2

Expression

• expressed in peripheral blood lympocytes, testis, ovary > spleen, thymus, prostate, small intestine, colon

Pathology

defects in KTN1 may be a cause of breast cancer

More general terms

• receptor
• glycoprotein
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3895
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3895
• OMIM: https://mirror.omim.org/entry/600381
• UniProt: http://www.uniprot.org/uniprot/Q86UP2.html