cytochrome P450 51; sterol 14-alpha demethylase; lanosterol 14-alpha demethylase (CYPL1, P450L1, LDM, P450-14DM)

Function

• involved in cholesterol biosynthesis
• catalyzes C14-demethylation of lanosterol
• transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24- triene-3-beta-ol

Structure

belongs to the cytochrome P450 family

Compartment

microsome (putative)

Expression

• ubiquitously expressed
• highest levels in testis, ovary, adrenal, prostrate, liver, kidney & lung

More general terms

• cytochrome P450
• membrane protein
• demethylase

Database

• OMIM: https://mirror.omim.org/entry/601637
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1595
• UniProt: http://www.uniprot.org/uniprot/Q16850.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1595