high affinity immunoglobulin alpha & immunoglobulin mu Fc receptor (Fc alpha/mu receptor, FCAMR)

Function

• receptor for the Fc fragment of IgA & IgM
• binds IgA & IgM with high affinity & mediates their endocytosis
• may function in the immune response to microbes mediated by IgA & IgM

Structure

• N-glycosylated
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

cell membrane

Alternative splicing

named isoforms=4

Expression

• expressed by mesangial cells
• up-regulated by IFNG in mesangial cells

More general terms

• glycoprotein
• Fc receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8395
• OMIM: https://mirror.omim.org/entry/605484
• UniProt: http://www.uniprot.org/uniprot/Q8WWV6.html