collagen 22 alpha-1 (COL22A1)

Function

• acts as a cell adhesion ligand for skin epithelial cells & fibroblasts

Structure

• belongs to the fibril-associated collagens with interrupted helices (FACIT) family
• contains 16 collagen-like domains
• contains 1 TSP N-terminal (TSPN) domain
• contains 1 VWFA domain

Compartment

• secreted, extracellular matrix
• cytoplasm (putative)

Alternative splicing

named isoforms=2

Expression

• restrictive expression is observed at tissue junctions such as the myotendinous junction in skeletal & heart muscle, the articular cartilage-synovial fluid junction, or the border between the anagen hair follicle & the dermis in the skin
• deposited in the basement membrane zone of the myotendinous junction & the hair follicle & associated with the extrafibrillar matrix in cartilage

More general terms

• glycoprotein
• secreted protein
• collagen subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=169044
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:169044
• OMIM: https://mirror.omim.org/entry/610026
• UniProt: http://www.uniprot.org/uniprot/Q8NFW1.html