Zn+2 transporter ZIP8 (Zrt- & Irt-like protein 8, ZIP-8, solute carrier family 39 member 8, LIV-1 subfamily of ZIP Zn+2 transporter 6, LZT-Hs6, BCG-induced integral membrane protein in monocyte clone 103 protein, SLC39A8, BIGM103, ZIP8, PP3105)

Function

acts as a Zn+2-influx transporter

Structure

belongs to the ZIP transporter (TC 2.A.5) family

Compartment

• membrane (putative)
• associated with the lysosomal/endosomal compartment following transfection

Alternative splicing

named isoforms=2

Expression

• expressed in thymus, placenta, lung, liver, pancreas > spleen, testis, ovary, small intestine, colon, leukocyte, heart
• highest expression is observed in pancreas
• induced by live & heat-killed Mycobacterium bovis bacterial cell wall & inflammatory cytokines like TNFA
• down-regulated following phorbol ester treatment

More general terms

• transmembrane 8e protein
• solute carrier family 39 (SLC39, SLC39A)
• glycoprotein
• Zn+2 transporter

Database

• OMIM: https://mirror.omim.org/entry/608732
• UniProt: http://www.uniprot.org/uniprot/Q9C0K1.html