UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (beta3Gn-T8, BGnT-8, beta-1,3-N-acetylglucosaminyltransferase-8, B3GNT8, B3GALT7, BGALT15)

Function

• beta-1,3-N-acetylglucosaminyltransferase
• plays a role in elongation of specific branch structures of multiantennary N-glycans
• strong activity towards tetraantennary N-glycans & 2,6 triantennary glycans
• forms a complex of enhanced enzymatic activity with B3GNT2 in vitro
• protein modification; protein glycosylation

Structure

belongs to the glycosyltransferase 31 family

Compartment

Golgi membrane (putative)

Expression

• highly expressed in small intestine, pancreas, spleen, bone marrow, lung, throat, & ileum, & weakly in fetal brain, cerebellum, heart, liver, tongue, breast, uteri, & testis
• not detected in colon

Pathology

• differentially expressed in human tumor cell lines
• up-regulated in colon cancer

More general terms

• glycoprotein
• beta-1,3-N-acetylglucoaminyltransferase (B3GNT1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z7M8.html