K+ voltage-gated channel subfamily A member 10 (voltage-gated K+ channel subunit Kv1.8, KCNA10)

Function

• mediates voltage-dependent K+ permeability of excitable membranes
• opened or closed conformations in response to voltage difference across the membrane
• K+-selective channel through which K+ may pass in accordance with electrochemical gradient
• channel activity is up-regulated by cAMP
• homotetramer
• interaction with KCN4B/POMP is necessary for modulation of channel activity by cAMP

Structure

• N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity &/or targeting of the channel tospecific subcellular compartments
• segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, A (Shaker) subfamily

Compartment

membrane

Expression

• detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium & in smooth muscle cells

More general terms

• voltage-gated K+ channel alpha subunit
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/602420
• UniProt: http://www.uniprot.org/uniprot/Q16322.html