protein CREG1 (cellular repressor of E1A-stimulated genes 1, CREG1, CREG, UNQ727/PRO1409)

Function

• may contribute to the transcriptional control of cell growth & differentiation
• antagonizes transcriptional activation & cellular transformation by the adenovirus E1A protein
• transcriptional control activity of cell growth requires interaction with IGF2R
• interacts with IGF2R; interaction dependent on glycosylation
• N-glycosylated

Structure

• homodimer
• belongs to the CREG family

Compartment

secreted

More general terms

• glycoprotein
• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/O75629.html